Céline MARIONNEAU

Céline Marionneau is an expert in phosphoproteomics and regulation of cardiac ion channels. The research goal developed in her team is to identify the molecular mechanisms mediating the post-translational regulation of cardiac ion channels. More specifically, she aims to identify novel signaling pathways, associated proteins, kinases, and post-translational modification (PTM) sites involved in regulating channel expression and function in health and disease. Her lab uses proteomic analyses of native cardiac ion channels, as well as biochemical and electrophysiological analyses from freshly isolated mouse cardiomyocytes to identify PTM sites and interacting proteins and to determine their roles in channel regulation. Ongoing research demonstrated that cardiac Nav1.5 channels are highly phosphorylated, comprising more than 50 phosphorylation sites, and that the mechanisms mediating phosphorylation-dependent channel regulation are far more complex than anticipated. By characterizing these post-translational regulations, her overall objective is to contribute to a better understanding of arrhythmia mechanisms and potentially to better arrhythmia treatments.

Research experiences:
From 2010: Principal Investigator, CNRS, Section #24, l'institut du thorax, Nantes Université
2018: Awarded HDR (Habilitation à Diriger des Recherches), Nantes Université
2009 - 2010: Postdoctoral fellow, l’institut du thorax, Nantes Université
2005 - 2008: Postdoctoral fellow, Washington University Medical School in Saint Louis, USA
2001-2005: PhD in biology, l'institut du thorax, Nantes Université

Research publications:
- Web of Science ResearcherID: D-4011-2015

- ORCID ID: 0000-0003-0962-9756

Research fundings:
2024-2028: ANR PRC

2023-2024: Fondation d’entreprise Genavie

2020-2025: NIH
2019-2020: Fondation d’entreprise Genavie
2017-2020: Paris scientifique régional Pays de la Loire

2016-2022: ANR DFG
2015-2019: ANR Jeune Chercheuse
2014-2015: Fondation d’entreprise Genavie
2013-2014: Fondation d’entreprise Genavie
2010-2013: Marie Curie International Reintegration Grant (European Commission)

2006-2008: American Heart Association (Heartland Affiliate)
2004-2005: Association Française contre les Myopathie (AFM)
2002-2004: French Ministry predoctoral fellowship

Teaching activities: Classes on Proteomics of ion channels (Licence 3 Advanced Biology Training and Master 2 InnoCARE, Faculty of Sciences, Nantes Université; Master 1, Sciences Biologiques Médicales, Faculty of Medicine, Nantes Université; Master 2, Biologie Santé, Faculty of Sciences, Université d'Angers

Open job, PhD and internship offers:
Technician/Engineer job offer
PhD offer
Licence and Master internship offers