Academic staff
Patricia LEMARCHAND
Professeure des Universités/biologie cellulaire - Praticien Hospitalier/pneumologieContact details
l'institut du thorax - Inserm UMR1087/CNRS UMR6291 IRS-UN, 8 quai Moncousu, BP 70721, 44007 Nantes cedex 1, France
- Phone
- 0228080133 (n° interne : 320133)
- Patricia.Lemarchand@univ-nantes.fr
Taught academic discipline(s)
Research topics
Gene and cell therapy, cellular models of cardiovascular disease using iPSCs.
Activities / Resume
Patricia Lemarchand has long been recognized and awarded for her work on respiratory and cardiovascular gene and cell therapy. She pioneered cardiovascular (Lemarchand et al, PNAS 1992; Circulation Research 1993) and respiratory (Danel et al, Human Gene Therapy 1998) gene therapy. She developed several approaches using adenovirus vectors (Foretz et al, Mol Cell Biol 1999; Tralhao et al, FASEB 2003).
Her research is currently based on translational research, from human stem-cell biology (MESSAGE study, NCT00836732) to cell therapy clinical trials (BONAMI clinical trial, NCT00200707, Roncalli et al, Eur Heart J 2011), including rodent and large animal models of gene and cell therapy (Ferrnandes et al, Cardiovasc Res 2006; Brazza et al, Stem Cells 2016).
Stimulated by the development of iPSC technologies, she has recently developed projects including iPSCs, considering their strong potential to develop new strategies in cell therapy and relevant models for cardiovascular diseases (Jouni et al, J Am Heart Assoc 2015; Si-Tayeb K et al, Disease Models & Mechanisms 2016). Together with Laurent David (scientific director), she coordinates the new iPSC core facility of Nantes, that prepares iPSCs for academic and industrial research projects. The iPSC core facility mainly focuses on human iPSCs from healthy individuals and patients with complex genetic diseases, to use these iPSCs to establish physiopathology models, and on rodent iPSCs dedicated to regenerative medicine and pre-clinical trials.Additional information
Main recent publications :
Lemarchand P, Hassoun D, Kuntz P. Questioning the relevance of sex categories implemented in medical decision support systems - The example of pulmonary function. ESSACHESS- Journal for Communication Studies 2024; 17 (1(33). https://doi.org/10.21409/8253-X893
Lemarchand Patricia, « La catégorie homme/femme à l’épreuve de la recherche biomédicale », dans : Patricia Lemarchand éd., Qu'est-ce qu'une femme ? Catégories homme/femme : débats contemporains. Paris, Éditions Matériologiques, « Essais », 2023, p. 23-67. DOI : 10.3917/edmat.lemar.2023.01.0025. URL : https://www.cairn.info/qu-est-ce-qu-une-femme--9782373614084-page-23.htm
Lemarchand Patricia, Salle Muriel, « Introduction. Qu’est-ce qu’une femme ? Question singulière, enjeux pluriels », dans : Patricia Lemarchand éd., Qu'est-ce qu'une femme ? Catégories homme/femme : débats contemporains. Paris, Éditions Matériologiques, « Essais », 2023, p. 3-15. DOI : 10.3917/edmat.lemar.2023.01.0005. URL : https://www.cairn.info/qu-est-ce-qu-une-femme--9782373614084-page-3.htm
Benkalfate N, Eschapasse E, Georges T, Leblanc C, Dirou S, Melscoet L, Chéné A-L, Horeau-Langlard D, Bry C, Chambellan A, Nicolas A, Defrance C, Liberge R, Karakachoff M, Hardouin JB, Blanc FX, Lemarchand P. Evaluation of the Post COVID-19 Functional Status (PCFS) scale in a cohort of patients recovering from hypoxemic SARS-CoV-2 pneumonia. BMJ Open Respiratory Research 2022; 9:e001136.
Al Sayed ZR, Jouni M, Gourraud JB, Nadjet Belbachir N, Barc J, Girardeau A, Forest F, Derevier A, Gaignerie A, Chariau C, Cimarosti B, Canac B, Olchesqui P, Charpentier E, Schott JJ, Redon R, Isabelle Baró I, Probst V, Charpentier F, Loussouarn G, Zibara K, Lamirault G, Lemarchand P*, Gaborit N*. A consistent arrhythmogenic trait in Brugada syndrome cellular phenotype. Clinical and Translational Medicine 2021;11(6):e413. *co-auteures correspondantes.
Al Sayed ZR, Canac R, Cimarosti B, Bonnard C, Hamamy H, Kayserili H, Girardeau A, Jouni M, Jacob N, Gaignerie A, Chariau C, David L, Forest V, Marionneau C, Loussouarn G, Lamirault G, Reversade B, Zibara K, Lemarchand P*, Gaborit N*. Human model of IRX5 mutations reveals key role for this transcription factor in ventricular conduction. Cardiovascular Research 2021; 117:2092-2107. *co-auteures correspondantes.
De Waard S, Montnach J, Ribeiro B, Nicolas S, Forest V, Charpentier F, Mangoni M, Gaborit N, Ronjat M, Loussouarn G, Lemarchand P, De Waard M. Functional impact of BeKm-1, a high affinity hERG blocker, on cardiomyocytes derived from human-induced pluripotent stem cells. International Journal of Molecular Sciences 2020; 21:7167-7171.
Dirou S, Chambellan A, Chevallier P, Germaud P, Lamirault G, Gourraud PA, Perrot B, Delasalle B, Forestier B, Guillaume T, Peterlin P, Garnier A, Magnan A, Blanc FX, Lemarchand P. Deconditioning, fatigue and impaired quality of life in long-term survivors after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplantation 2018; 53: 281-290.
Lamirault G, de Bock E, Sébille S, Delasalle B, Roncalli J, Susen S, Piot C, Trochu JN, Teiger E, Neuder Y, Le Tourneau T, Manrique A, Hardouin J-B, Lemarchand P. Sustained quality of life improvement after intracoronary injection of autologous bonemarrow cells in the setting of acute myocardial infarction: results from the BONAMI trial. Quality of Life Research 2017; 26:121-125.
Braza F, Dirou S, Forest V, Sauzeau V, Hassoun D, Chesné J, Cheminant-Muller M-A, Sagan C, Magnan A, Lemarchand P. Mesenchymal stem cells induce suppressive macrophages through phagocytosis in a mouse model of asthma. Stem Cells 2016; 209:258-265.
Es-Salah-Lamoureux Z, Jouni M,Malak OA, Belbachir N, Reda Al Sayed Z, Gandon-Renard M, Lamirault G, GauthierC, Baró I, Charpentier F, Zibara K, Lemarchand P, Beaumelle B, Gaborit N, Loussouarn G. HIV-Tat induces a decrease in IKr and IKs via reduction in phosphatidylinositol-(4,5)-bisphosphate availability. Journal of Molecular and Cellular Cardiology 2016; 99:1-13.
Jouni M, Si-Tayeb K, Es-Salah-Lamoureux Z, Latypova X, Champon B, Caillaud A, Rungoat A, Charpentier F, Loussouarn G, Baró I, Zibara K, Lemarchand P, Gaborit N. Towards Personalized Medicine: Using cardiomyocytes differentiated from urine-derived pluripotent stem cells to recapitulate electrophysiological characteristics of LQT2 syndrome. J Am Heart Assoc 2015;4:e002159.
Gyongyosi M, Wojakowski W, Lemarchand P, et al. Meta-Analysis of Cell-basedCaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data. Circ Res 2015 16(8):1346-60. Best manuscript award 2015.
Roncalli J, Mouquet F, Piot C, Trochu JN, Le Corvoisier P, Neuder Y, Le Tourneau T, Agostini D, Gaxotte V, Sportouch C, Galinier M, Crochet D, Teiger E, Richard MJ, Polge AS, Beregi JP, Manrique A, Carrie D, Susen S, Klein B, Parini A, Lamirault G, Croisille P, Rouard H, Bourin P, Nguyen JM, Delasalle B, Vanzetto G, Van Belle E, Lemarchand P. Intracoronary autologous mononucleated bone marrow cell infusion for acute myocardial infarction: results of the randomized multicenter BONAMI Trial. Eur Heart J 2011; 32(14): 1748-1757.