Thesis defense Samuel Frey
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Le 23 October 2023Amphi DEfalse false
Title of the thesis : Impact of bariatric surgeries on the cholesterol metabolism: identification of the molecular mechanisms
Equipe
Team IV - Cardiometabolic disease
Directrice de thèse
Co-directeur
Rapporteurs
Judith Aron-Wisnewsky, PUPH, Sorbonne Université / Pitié Salpêtrière
René Valero, PUPH, Université d’Aix-Marseille
Examinateurs
Éric Mirallié, PUPH, Nantes Université / CHU de Nantes
Maud Robert, PUPH, Université Lyon 1 / Hospices Civiles de Lyon
Abstract
Obesity is a major public health issue which concerns approximately 20% of the population worldwide. It is associated with multiple comorbidities including diabetes and dyslipidemia. Bariatric surgeries, which constantly evolve, have emerged as an efficient therapy, allowing content weight loss and metabolic benefits. This work aimed to decipher the molecular mechanisms involved in the hypocholesterolemic effects of bariatric surgeries. In a first time, we studied the role of a major actor of the cholesterol metabolism, the intestinal low-density lipoprotein receptor (LDLR), on the hypocholesterolemic effects of the Roux-en-Y gastric bypass (RYGB), which is the gold standard procedure. We showed that, in mice, the intestinal LDLR deficiency was associated with a reduced hypocholerolemic effect after RYGB related to a higher intestinal cholesterol absorption and altered fecal bile acids excretion. |